Protein Details: Gap junction alpha-3 protein

Protein ID

ICDB_Pro_1722

Protein Name

Gap junction alpha-3 protein

Gene Name

GJA3

Organism

Homo sapiens (Human)

Length

435 amino acids

AlphaFoldDB

AF-Q9Y6H8-F1-model_v4.pdb

Function

Sequence

MGDWSFLGRLLENAQEHSTVIGKVWLTVLFIFRILVLGAAAEDVWGDEQSDFTCNTQQPGCENVCYDRAFPISHIRFWALQIIFVSTPTLIYLGHVLHIVRMEEKKKEREEEEQLKRESPSPKEPPQDNPSSRDDRGRVRMAGALLRTYVFNIIFKTLFEVGFIAGQYFLYGFELKPLYRCDRWPCPNTVDCFISRPTEKTIFIIFMLAVACASLLLNMLEIYHLGWKKLKQGVTSRLGPDASEAPLGTADPPPLPPSSRPPAVAIGFPPYYAHTAAPLGQARAVGYPGAPPPAADFKLLALTEARGKGQSAKLYNGHHHLLMTEQNWANQAAERQPPALKAYPAASTPAAPSPVGSSSPPLAHEAEAGAAPLLLDGSGSSLEGSALAGTPEEEEQAVTTAAQMHQPPLPLGDPGRASKASRASSGRARPEDLAI

PDB Structures

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

Disease

Cataract 14;Multiple Types and Congenital Cataracts;Facial Dysmorphism;And Neuropathy

Location

DOI ID

10.1086/302383; 10.1038/nature02379; 10.1101/gr.2596504; 10.1007/s004390051029; 10.1136/jmg.2004.018333; 10.1136/bjo.2005.075184; 10.1167/iovs.08-3149; 10.1002/humu.21552; 10.1089/dna.2015.3125; 10.1534/g3.117.300109; 10.1097/opx.0000000000000518; 10.1152/ajpcell.00157.2018

RefSeq

NP_068773.2; XP_011533350.1